abstract：:This study aims to explore the protective effects and mechanisms of ulinastatin (UTI), which is a urinary trypsin inhibitor, of the renal interstitial fibrosis of rats subjected to unilateral ureteral obstruction (UUO). A total of 36 male Wistar rats were divided in random into three groups, namely, the sham operation...

journal_title：International immunopharmacology

authors： Ning XH,Ge XF,Cui Y,An HX

更新日期：2013-02-01 00:00:00

abstract：:Avian thymic hormone (ATH) is a β-parvalbumin produced by epithelial cells in the thymic cortex and in the eyes of chickens. Chicken parvalbumin 3 (CPV3) is a homologous protein produced in the thymus and in hair cells of the chicken ear. ATH circulates in the blood on a five-day cycle and stimulates cell-mediated imm...

journal_title：International immunopharmacology

authors： Novak Kujundžić R,Steffens WL,Brewer JM,Henzl MT,Ragland WL

更新日期：2013-02-01 00:00:00

abstract：:We assessed the effects of Zizyphus lotus L. (Desf.) polyphenols (ZLP) on T-cell signaling and proliferation. Our results showed that ZLP exerted no effect on the increases in intracellular free calcium concentrations, [Ca(2+)]i, in human Jurkat T-cells. However, ZLP modulated the thapsigargin-induced increases in [Ca...

journal_title：International immunopharmacology

authors： Abdoul-Azize S,Bendahmane M,Hichami A,Dramane G,Simonin AM,Benammar C,Sadou H,Akpona S,El Boustani ES,Khan NA

更新日期：2013-02-01 00:00:00

abstract：:The hematopoietic system is sensitive to radiation injury, and mortality can occur due to blood cell deficiency and stem cell loss. Genistein and the angiotensin converting enzyme (ACE) inhibitor captopril are two agents shown to protect the hematopoietic system from radiation injury. In this study we examined the com...

journal_title：International immunopharmacology

authors： Day RM,Davis TA,Barshishat-Kupper M,McCart EA,Tipton AJ,Landauer MR

更新日期：2013-02-01 00:00:00

abstract：:The aims of this study were to elucidate the immunomodulatory effects of glycyrrhizin (GL) on CD4(+)T cell responses during liver fibrogenesis. To obtain in vivo evidence about the effects of GL on CD4(+)T cells in livers and spleens of concanavalin A (ConA)-induced mouse model, mice were administrated with ConA toget...

journal_title：International immunopharmacology

authors： Tu CT,Li J,Wang FP,Li L,Wang JY,Jiang W

更新日期：2012-12-01 00:00:00

abstract：:Myagropsis myagroides has been used as a Chinese medicine and its extract has shown various biological activities, however, its anti-inflammatory mechanism remains unknown. In this study, we investigated the inhibitory effects of the ethyl acetate fraction of M. myagroides (EFM) on the production of inflammatory media...

journal_title：International immunopharmacology

authors： Joung EJ,Lee MS,Choi JW,Kim JS,Shin T,Jung BM,Kim JI,Kim HR

更新日期：2012-12-01 00:00:00

abstract：:TanshinoneIIA, an active component derived from a traditional Chinese medicine, has anti-inflammatory and anti-cancer effect. However, the mechanisms underlying the interaction between anti-inflammation and anti-cancer of TanshinoneIIA remain elusive. In the present study, a cell model of inflammation between macropha...

journal_title：International immunopharmacology

authors： Tu J,Xing Y,Guo Y,Tang F,Guo L,Xi T

更新日期：2012-12-01 00:00:00

abstract：:We recently designed a series of N-[4-(t-amino-yl)-but-2-yn-1-yl] isoindoline-1,3-diones as anti-inflammatory compounds, called ZM compounds. These ZM compounds were categorized according to the nature of the cyclic amino groups into ZM2, ZM3, ZM4, and ZM5 and were shown to reduce carrageenan-induced inflammation, inh...

journal_title：International immunopharmacology

authors： Matalka KZ,Alfarhoud F,Qinna NA,Mallah EM,Abu-Dayyih WA,Muhi-eldeen ZA

更新日期：2012-11-01 00:00:00

abstract：:Paeonia lactiflora Pallas, also named Chinese Paeony, is a Chinese herb. A decoction of its root has been used to treat painful or inflammatory disorders in traditional Chinese medicine. A water/ethanol extract of Radix Paeoniae is known as total glycosides of paeony (TGP), of which paeoniflorin is the major active co...

journal_title：International immunopharmacology

authors： Zhang W,Dai SM

更新日期：2012-09-01 00:00:00

abstract：:Streptococcus pneumoniae is a primary cause of invasive bacterial infection and pneumonia and is one of the leading causes of death worldwide. In prior studies we showed that pre-treating mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a potent agonist of the aryl hydrocarbon receptor (AhR), protects against S. ...

journal_title：International immunopharmacology

authors： Wang T,Wyrick KL,Pecka MR,Wills TB,Vorderstrasse BA

更新日期：2012-08-01 00:00:00

abstract：:The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanisms, diagnosis and treatments of cancer. In this study, we employed AFFX miRNA expression chips to search for miRNAs that may be aberrantly expressed in gastric cancer tissues and to investigate the potential roles that miRNAs...

journal_title：International immunopharmacology

authors： Su Y,Ni Z,Wang G,Cui J,Wei C,Wang J,Yang Q,Xu Y,Li F

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Many studies have shown that ghrelin can down-regulate inflammatory cytokine expression via the inhibition of NF-κB activity and therefore, its administration to septic patients is considered beneficial. However, our knowledge of ghrelin's effects on the upstream activators of the NF-κB pathway, such as NOD2...

journal_title：International immunopharmacology

authors： Peng Z,Zhu Y,Zhang Y,Wilhelmsen K,Jia C,Jin J,Xue Q,Feng X,Zhang F,Yu B

更新日期：2012-08-01 00:00:00

abstract：:The purpose of this review is to collate current knowledge and recent advances in molecular mechanism behind the immediate type hypersensitivity of foods. Food allergy is a growing concern of human health in developed as well as developing countries now days. Food allergic reactions are mostly IgE mediated and also kn...

journal_title：International immunopharmacology

authors： Kumar S,Verma AK,Das M,Dwivedi PD

更新日期：2012-08-01 00:00:00

abstract：:Lipoteichoic acid (LTA) is a major virulence factor of Gram-positive bacteria including Staphylococcus aureus. Despite its pivotal role in causing sepsis, the systemic immune responses to LTA in human cells are poorly understood. Here, we produced highly-pure and structurally-intact LTA from S. aureus and examined the...

journal_title：International immunopharmacology

authors： Kang SS,Kim HJ,Jang MS,Moon S,In Lee S,Jeon JH,Baik JE,Park OJ,Son YM,Kim GR,Joo D,Kim H,Han JY,Yun CH,Han SH

更新日期：2012-08-01 00:00:00

abstract：:The use of dendritic cell (DC) vaccines as treatment for malignancy is complicated by immune evasion tactics often employed by carcinomas such as head and neck squamous cell carcinoma (HNSCC). The present study aims to determine if an immune response can be elicited by administering a DC vaccine during the premalignan...

journal_title：International immunopharmacology

authors： De Costa AM,Justis DN,Schuyler CA,Young MR

更新日期：2012-07-01 00:00:00

abstract：:Immune thrombocytopenic purpura associated with multiple myeloma is extremely rare. Here, we present the successful management of an elderly Japanese patient with multiple myeloma complicated by immune thrombocytopenia with low dose cepharanthine - a plant derived alkaloid. A 78-year-old male patient with IgGκ multipl...

journal_title：International immunopharmacology

authors： Tabata R,Tabata C,Tazoh A,Nagai T

更新日期：2012-07-01 00:00:00

abstract：:Allergic asthma has emerged as an important public health problem of urban populations in developed countries. Very often herbal medicine is used to treat this widespread disease, due to the lack of efficacy and the important side effects related to the classical drugs in use. Along this line, Ocimum gratissimum (Og) ...

journal_title：International immunopharmacology

authors： Costa RS,Carneiro TC,Cerqueira-Lima AT,Queiroz NV,Alcântara-Neves NM,Pontes-de-Carvalho LC,Velozo Eda S,Oliveira EJ,Figueiredo CA

更新日期：2012-05-01 00:00:00

abstract：:Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy in Korea. Skullcapflavone II antagonized the bradykinin receptor more potently than any of the other flavonoids derived from this plant. Here, we were investigated its thera...

journal_title：International immunopharmacology

authors： Jang HY,Ahn KS,Park MJ,Kwon OK,Lee HK,Oh SR

更新日期：2012-04-01 00:00:00

abstract：:Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has been proven to be an anti-cancer agent. Its anti-inflammatory activities have recently been observed both in in vitro and in vivo models. Yet its action on lymphocytes and the underlying mechanism are still not well known. In this study, in o...

journal_title：International immunopharmacology

authors： Shi ZJ,Ouyang DY,Zhu JS,Xu LH,He XH

更新日期：2012-04-01 00:00:00

abstract：:Antarctic bacteria are a novel source of polysaccharides which might have potential applications as biological response modifiers (BRM). A heteropolysaccharide (PEP) was isolated from the liquid culture broth of the Antarctic bacterium Pseudoaltermonas sp.S-5. PEP contained Mannose, Glucose, and Galactose in a ratio o...

journal_title：International immunopharmacology

authors： Bai Y,Zhang P,Chen G,Cao J,Huang T,Chen K

更新日期：2012-04-01 00:00:00

abstract：:The activities of dectin-1 and mannose receptors on phagocytosis of Candida albicans and the production of TNF-α by macrophages from mice pretreated for 3 days with extract of Artocarpus intergrifolia seeds (jack extract), Artin M or jacalin were studied. Macrophages from these mice were coincubated with C. albicans C...

journal_title：International immunopharmacology

authors： Loyola W,Custodio LA,Felipe I,Conchon-Costa I,Carvalho PG,Quirino GF,Silva LF,Gaziri LC

更新日期：2012-02-01 00:00:00

abstract：:It has been reported that treatment with cyclophosphamide (CTX) as a chemotherapeutic drug in cancer patients or tumor-bearing mice can result in an increase in the proportion of myeloid derived suppressor cells (MDSCs) in blood and lymphoid organs. Here we sought to clarify the possible mechanism of this unwanted inc...

journal_title：International immunopharmacology

authors： Guo Q,Lv Z,Fu Q,Jiang C,Liu Y,Lai L,Chen Q,Shen J,Wang Q

更新日期：2012-02-01 00:00:00

abstract：:Antipsychotic drugs (APDs) that bind mainly to the dopamine D2 receptor or the type II 5-HT receptor have been used to ease the symptoms of schizophrenia. Several studies have reported that APDs can also regulate the immune response. Dendritic cells (DCs) are the major antigen-presenting cells in the immune system. DC...

journal_title：International immunopharmacology

authors： Chen ML,Tsai TC,Wang LK,Lin YY,Tsai YM,Lee MC,Tsai FM

更新日期：2012-01-01 00:00:00

abstract：:In the presence of TGF-β, CD4+CD62L+T cells can be induced to CD4+CD25+FoxP3+ regulatory T cells (iTregs). In our previous work, we have shown that adoptive transfer of iTregs promoted liver recovery from ischemia reperfusion injury (IRI). In this study, we examined the molecular mechanism underlying the liver IRI att...

journal_title：International immunopharmacology

authors： Feng M,Wang Q,Zhang F,Lu L

更新日期：2012-01-01 00:00:00

abstract：:Members of the tumor necrosis factor (TNF) family play key roles in the regulation of inflammation, immune responses and tissue homeostasis. Here we describe the identification of the Japanese sea perch (Lateolabrax japonicus) homologue of mammalian B cell activating factor of the TNF family (BAFF/BLyS) (designated Lj...

journal_title：International immunopharmacology

authors： Cui XW,Li JF,Xiao W,Xuan Y,Tian AY,Xu XZ,Zhang SQ

更新日期：2012-01-01 00:00:00

abstract：:Ampelopsin (AMP), a plant flavonoid, has potent anti-inflammatory properties in vitro and in vivo. The molecular mechanisms of ampelopsin on pharmacological and biochemical actions of RAW264.7 macrophages in inflammation have not been clearly elucidated yet. In the present study, non-cytotoxic level of ampelopsin sign...

journal_title：International immunopharmacology

authors： Qi S,Xin Y,Guo Y,Diao Y,Kou X,Luo L,Yin Z

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Activation of nuclear factor-kappa B (NF-κB), which controls transcription of various pro-inflammatory cytokine genes, has been shown to play a critical role in the pathogenesis of ulcerative colitis (UC). Parthenolide, a sesquiterpene lactone compound isolated from extracts of the herb Feverfew (Tanacetum p...

journal_title：International immunopharmacology

authors： Zhao ZJ,Xiang JY,Liu L,Huang XL,Gan HT

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the anti-inflammatory potential of ICT in LPS stimulated human innate immune cells. BACKGROUND:3, 5, 7-Trihydroxy-4'-methoxy-8-(3-hydroxy-3- methylbutyl)-flavone (ICT) is a novel derivative of icariin, the major active ingredient of Herba Epimedii, an herb used in traditional Chinese medicine. We...

journal_title：International immunopharmacology

authors： Wu J,Zhou J,Chen X,Fortenbery N,Eksioglu EA,Wei S,Dong J

更新日期：2012-01-01 00:00:00

abstract：:The transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig), a recombinant fusion protein that modulates B and T cells activation by binding and neutralizing B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), has been shown to have a therapeutic...

journal_title：International immunopharmacology

authors： Qin Q,Chang Y,Wang D,Wu Y,Zhang LL,Wei W

更新日期：2011-12-01 00:00:00

abstract：:This study was designed to determine the level of survivin expression and its clinical significance as a prognostic factor in gastrointestinal stromal sarcoma (GIST). Twenty patients (12 males and 8 females) ranging in age from 25 to 72, with a median age of 53 were evaluated. Failure of TKI treatment was higher in th...

journal_title：International immunopharmacology

authors： Baykara M,Akkus M,Yildiz R,Gonul II,Dursun A,Coskun U,Benekli M,Sevinc A,Dane F,Buyukberber S

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Development of agents that specifically kill cancer cells and simultaneously elicit antitumor immune response is a step forward in cancer therapy. In the present study, we investigated whether the administration of artemether contributes to the augmentation of antitumor immunity and the regression of tumor t...

journal_title：International immunopharmacology

authors： Farsam V,Hassan ZM,Zavaran-Hosseini A,Noori S,Mahdavi M,Ranjbar M

更新日期：2011-11-01 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is an immunomodulating agent that induces beneficial therapeutic responses in children and adults. IVIG is not only used for prophylaxis and therapy of infections in patients with primary and secondary immunodeficiencies associated with defective antibody production, but also used for...

journal_title：International immunopharmacology

authors： Baxley A,Akhtari M

更新日期：2011-11-01 00:00:00

abstract：:Histamine plays major roles in allergic diseases and its action is mediated mainly by histamine H(1) receptor (H1R). We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects severity of the allergic sympto...

journal_title：International immunopharmacology

authors： Nurul IM,Mizuguchi H,Shahriar M,Venkatesh P,Maeyama K,Mukherjee PK,Hattori M,Choudhuri MS,Takeda N,Fukui H

更新日期：2011-11-01 00:00:00

abstract：:Innate immune cells have evolved to sense microbial pathogens through pattern recognition receptors (PRRs), which interact with conserved pathogen-associated molecular patterns (PAMPs) to convey microbial information into immune cell signaling and activation events. PRRs also recognize endogenous damage-associated mol...

journal_title：International immunopharmacology

authors： Davicino RC,Eliçabe RJ,Di Genaro MS,Rabinovich GA

更新日期：2011-10-01 00:00:00

abstract：:Calcineurin (CaN) plays an important role in glomerular hypertrophy and extracellular matrix accumulation in early diabetic nephropathy. Cyclosporine (CSA), a CaN inhibitor, has been shown to reduce renal injury in streptozotocin-induced diabetic rats. We examined whether FK506, which immunosuppressive action was 10-1...

journal_title：International immunopharmacology

authors： Qi XM,Wu YG,Liang C,Zhang P,Dong J,Ren KJ,Zhang W,Fang F,Shen JJ

更新日期：2011-10-01 00:00:00

abstract：:DA-9601 (Stillen™) is a novel anti-peptic formulation prepared from the ethanol extracts of Artemisia asiatica possessing anti-oxidative, anti-allergic and anti-inflammatory activities. However, their effect on atopic dermatitis (AD) has not been studied yet. In this study, we report that topical application of DA-960...

journal_title：International immunopharmacology

authors： Choi EJ,Lee S,Hwang JS,Im SH,Jun CD,Lee HS,Kim SH

更新日期：2011-09-01 00:00:00

abstract：:Ischemia and reperfusion injury (IR) is an antigen independent inflammatory process that causes tissue damage. After IR, kidneys up-regulate leukocyte adhesion molecules and toll-like receptors (TLRs). Moreover, injured kidneys can also secrete factors (i.e. heat shock protein) which bind to TLRs and trigger intracell...

journal_title：International immunopharmacology

authors： Pedregosa JF,Haidar AA,Hirata AE,Franco M,Gomes GN,Bueno V

更新日期：2011-09-01 00:00:00

abstract：:Stingrays from the Potamotrygon cf. henlei species are widely distributed in high numbers throughout the rivers of central-west Brazil, being the source of numerous envenomations occurring in the dry season, posing a serious public health problem even if not properly reported. The accidents usually involve fishermen a...

journal_title：International immunopharmacology

authors： Monteiro-dos-Santos J,Conceição K,Seibert CS,Marques EE,Silva PI Jr,Soares AB,Lima C,Lopes-Ferreira M

更新日期：2011-09-01 00:00:00

abstract：:IL-10 producing regulatory type 1 (Tr1) cells represents a subpopulation of CD4+ regulatory cells able to prevent in vitro bystander T-cell proliferation and to inhibit a wide range of inflammatory diseases in mice. Our aim was to evaluate the frequency and function of joint specific Tr1 cells in the peripheral blood ...

journal_title：International immunopharmacology

authors： Brun V,Neveu V,Pers YM,Fabre S,Quatannens B,Bastian H,Clerget-Chossat N,Jorgensen C,Foussat A

更新日期：2011-08-01 00:00:00

abstract：:Current evidence indicates that semicarbazide-sensitive amine oxidase (SSAO) substrates possess insulin-mimic effect, which was thought to play an anti-inflammatory role. The purpose of the present study was to determine whether SSAO substrates benzylamine (BZA) and methylamine (MA) attenuate inflammatory response ind...

journal_title：International immunopharmacology

authors： Lin Z,Li H,Luo H,Zhang Y,Luo W

更新日期：2011-08-01 00:00:00